The Department of Health and Human Services (HHS) supports a broad portfolio of research related to environmental health and the health effects of global change. The National Institutes of Health (NIH) supports USGCRP research on the health effects of air pollution and temperature, water quality and quantity, infectious disease transmission, and materials used in new technologies to mitigate or adapt to climate change.

The National Institute of Environmental Health Sciences (NIEHS) supports research on the health effects of air pollution and temperature, agricultural chemicals, and materials used in new technologies to mitigate or adapt to climate change.  They also sponsor a research program on the human health impacts of climate change.

The Centers for Disease Control and Prevention (CDC) is also engaged in a number of activities related to climate change, such as researching emerging and reemerging infectious diseases. For more information on climate change work at CDC, see their Climate Change and Public Health website.